The aging process tends to damage the neurons present in our brains using the free radicals. The biologists from MIT have thus found the free radical damage is commonly known as the oxidative stress wherein the atypical stocking of the short snippets of RNA in certain neurons takes place. According to the researchers, this RNA pileup may be designated as the marker of the neurodegenerative diseases that can help bring down the protein production. The researchers have used the human brain region striatum which is the site for Parkinson’s and Huntington’s and the mouse brain to study the current neuron damaging process.
According to Christopher Burge from MIT, the metabolically active brain, in the long run, tends to have some of its neurons damaged due to the oxidative stress releasing the free radicals. The current oxidative stress processes consequences have previously not been studied and even the effects on the genes along with the global regulation or translation of the RNA. The researchers Myriam Heiman and Christopher Burge have made it a point to get to the core of the process and come up with a potential solution. The researchers were able to separate out the sequence messenger RNA from particular types of cells using Heiman’s technique. The green fluorescent protein usage in ribosome tagging in the Heiman’s technique helps differentiate the various types of neurons and glia knotted together and lastly isolates mRNA from a specific type of cells.
The researchers focused on two specific neurons that play an important role in the several neurodegenerative diseases along with the aging-related factor so as to get a better idea about the normal aging processes influence on the molecular and cellular properties. The D1 Neurons had genes expressed having only a small piece of the mRNA sequence known as the 3′ untranslated regions attached to the ribosomes and preventing it from assembling proteins. The neurons use a lot of energy that leads to free radicals formation which can damage the neurons itself in the long run. Along with the oxidative stress, the environmental and genetic factors could lead to cellular damage which can further decline cognitive ability. University of Queensland researcher Trent Woodruff has also found a potent therapy to end Parkinson’s disease at the time of onset itself by focusing on the tiny molecule, MCC950, which had played a role in halting the progression of Parkinson’s in the animals. The team is set to experiment it out on the humans by 2020.
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