A fast progress from directed therapies for cancer is shifting how clinical tests are carried and for researchers and drug companies in this process, new challenges are increasing. Presently, approvals for novel cancer medicines are frequently backed by information from a few hundred patients or fewer. These patients are cautiously selected and screened for genetic deformities made targetable by advancement in sequencing and therapy.
Dr. Norman Sharpless—Director of the NCI (National Cancer Institute)—in an interview at the ASH’s (American Society of Hematology) annual meeting in San Diego stated that presently, modernizing the clinical test infrastructure is truly a significant challenge for research of cancer. Dr. Sharpless further compared the costly clinical researches used to examine chemotherapies to latest datasets that have revealed impressive advantage with far fewer patients. He said, “The reason that is happening is since—rather than having 1,000 patient examinations where everybody is diverse and the variation between results is 2%—we are performing 80 or 120 patient trials, but they are all defined molecularly.”According to Dr. Sharpless “We are correlating apples to apples and not apples with oranges.”
Recently, the NCI was in news for declaring the completion of enrollment for the ABCD (Adolescent Brain Cognitive Development). The institute also stated that in early of 2019, researchers would have entry to baseline information from all ABCD study participants. The study was conducted with almost 11,874 youngsters, aged from 9–10 Years, participating in the study, counting 2,100 youngsters who were twins or triplets. The ABCD study is a critical study on the brain development and kids’ health that will add to the understanding of social, environmental, genetic, and other biological aspects that influences the brain and cognitive development and could improve or disrupt a kid’s life trajectory. Coordinated by the NIDA (National Institute on Drug Abuse) and the NIAAA (National Institute on Alcohol Abuse and Alcoholism), this research is backed by eight other NIH offices and institutes, as well as the CDC (Centers for Disease Control and Prevention).
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