Scientists Find Clues To Brain Modifications While In Depression

Scientists Find Clues To Brain Modifications While In Depression

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In new pre-clinical study, researchers at the UMSOM (University of Maryland School of Medicine), spearheaded by Professor of Physiology, Scott Thompson, have recognized modifications in brain activity connected to the reward and pleasure system.

The study, posted in the Nature journal, offers news insights into how the brain advances our understanding of depression & addiction and processes rewards. The study, which was carried out by a Research Associate in the Department of Physiology, Tara LeGates, found that the strength of signals among 2 brain areas, the nucleus accumbens and the hippocampus, is essential for processing data associated to a rewarding stimulus.

“These two regions of the brain are dubbed to be essential in processing experiences related to rewards,” claimed Dr. Thompson. The communication among these areas is stronger in addiction, even though the mechanisms behind this were not known. We also found that opposite modifications in the level of this communication might occur in depression.

Speaking of brain cells, researchers expecting to design better cures for kidney disease have turned their concentration in the lab to increasing clusters of kidney cells. The supposed organoids (developed from human stem cells) might assist cure damaged kidneys in individuals or can be employed to test drugs designed to battle kidney disease.

But new study in St. Louis from Washington University School of Medicine has verified rogue cells (namely muscle and brain cells) loitering inside kidney organoids. Such cells compose of just 10–20% of an organoid’s cells, the researchers found. But their presence means that the “recipes” employed to entice stem cells into turning kidney cells unintentionally are manufacturing other types of cell.

The scientists discovered a simple method to avoid most of those wayward cells from manufacturing, and that same method can be used by other researchers who find rogue cells in different organoids, such as those of the lung, brain, or heart. The research is posted in Cell Stem Cell.

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