Study Shows New Opportunities To Reverse Or Slow Multiple Sclerosis

Study Shows New Opportunities To Reverse Or Slow Multiple Sclerosis

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Nerve cells deprived of their insulation can no longer transfer vital data, resulting in the weakness, numbness, and vision issues often related with multiple sclerosis (MS). A new research demonstrates that an overlooked source might be capable of replacing that lost insulation and offer a new method to cure diseases such as MS.

Cells dubbed as neurons compose the central nervous system operations by transferring electrical signals alongside threadlike links known as axons. Axons do their job best when covered in an insulating layer of myelin (a fatty substance).

“When you are short of myelin, axons don’t conduct or do not do their job at their normal speed,” claims neuroscientist at the School of Veterinary Medicine of University of Wisconsin-Madison, Ian Duncan, to the media in an interview. “And if noteworthy amount of them are impacted (such as in a big region of demyelination) you get clinical indications associated to nervous system’s that part.”

On a related note, multiple sclerosis is an autoimmune disorder in which the person’s own immune system damages and attacks myelin. This is the reason as to why efforts to find the target antigen of the disease have so far aimed on the components of myelin membrane. New results made by the research team of Roland Martin and Mireia Sospedra from the Clinical Research Priority Program Multiple Sclerosis of University of Zurich now recommend that it is worth expanding the research viewpoint to attain a better understanding of the pathological procedures.

In the Science Translational Medicine journal, the researchers claimed that T cells (the immune cells accountable for pathological procedures) react to a protein dubbed as GDP-L-fucose synthase. “We think that the immune cells are triggered in the intestine and then travel to the brain, where they create an inflammatory cascade when they interact with the human version of their target antigen,” claims Mireia Sospedra.

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